Chemobrain refers to a syndrome (a bunch of symptoms) that some people get when they take chemotherapy drugs. Chemotherapy is a systematic treatment, meaning it goes all over the body. An unfortunate side effect of many chemotherapy agents is a diminshment in mental energy and acuity. As a stimulant, modafinil has found some interest from doctors for treatment of this condition.
A recent University of Rochester study showed that modafnil is effective in treatment of chemobrain
.A phase III clinical trial of modafinil on people taking the chemotherapy drug doclataxel found "modest" benefit for the fatigue those patients experience.